现任暨南大学基础医学与公共卫生学院系统生物医学系主任，博士，教授，博士生导师。在澳大利亚取得生物信息学本科（荣誉学士）和博士学位。在博士后期间参与主导了ChIA-PET三维基因组解析技术的研发及后续数据的处理，使得该技术得以能够揭示单倍型特异性的染色质三维结构、基因组结构变异与疾病的关系。同时长期从事基因组、转录组和三维基因组等生物医学大数据分析，取得了丰硕的研究成果。目前亦专注于机器学习技术在生物医疗大数据研究中的研发与应用。以项目负责人身份主持国家自然科学基金项目两项，广州市科技计划基础研究计划民生科技项目一项，获得中央组织部海外高层次引进人才项目青年人才项目和广东省珠江人才计划引进高层次人才青年拔尖项目支持， 主要参与人身份参与国家自然科学基金重点支持项目和国家科技部重点研发计划各一项，致力于机器学习技术在单细胞测序、T细胞受体组库和其他生物医学多组学大数据分析中的开发和应用。
2007.8–2011.6, 澳大利亚国立大学, 医学科学, 博士；
2002.7–2006.6, 澳大利亚新南威尔士大学, 生物信息学, 工程学士（Hounors degree）。
2019.6-至今, 暨南大学, 基础医学与公共卫生学院, 教授；
2016.8-2019.5, 澳大利亚联邦科学与工业研究组织, Health & Biosecurity, 研究员（Tenured)；
2016.3-2016.7, 美国杰克逊实验室基因组医学研究所, Genome Sciences, 助理研究员；
2012.9-2016.3, 美国杰克逊实验室基因组医学研究所, Genome Sciences, 博士后，合作导师: 阮一骏；
2011.7-2012.9, 新加坡基因组研究所(GIS), Genome Technology and Biology, 博士后，合作导师: 阮一骏；
2006.7-2007.7, 澳大利亚悉尼大学, 兽医学院, 生物信息科研员。
1. 国家自然科学基金委，重大研究计划培育项目，新冠病毒T细胞抗原表位变异的免疫逃逸机制研究。项目编码: 92169102。项目预算：60万元。2022/01/01-2024/12/31
2. 国家自然科学基金委：NSFC-广东联合基金重点支持项目，流感病毒抗原特异性TCR组库数据库的建立及应用。项目编码: U1801285。项目预算：245万元。2019/01/01-2022/12/31
3. 国家科技部，国家重点研发计划“主动健康与老龄化科技应对”重点专项，“中国老年人群衰弱的诊断标准及综合干预研究”专项，课题“基于新方法新技术的老年衰弱早期预测和诊断研究”总负责人，华南区召集人。项目编码：2018YFC2002003。项目预算：488万。2019/01/01-2023/12/31
4. 广州市科技计划项目：单细胞水平TCR组学高通量测序技术的建立与应用。项目编码：201904010111，项目预算：20万元。2019/04/01-2022/03/31
5. 国家自然科学基金委：应急项目，单细胞转录组学和TCR组学分析老年人巨细胞病毒和流感病毒抗原特异性CD8 T细胞免疫应答的差异研究。项目编码：31741037，项目预算：15万元。2018/01/01-2018/12/31
6. 广东省建设高水平大学人才引进项目：T淋巴细胞TCR组库的鉴定及功能研究。项目预算：100万元。2018/01/01-2023/12/31
1. 国家自然科学基金委，重大研究计划培育项目，新冠病毒T细胞抗原表位变异的免疫逃逸机制研究。项目编码: 92169102。项目预算：60万元。2022/01/01-2024/12/31
2. 国家自然科学基金委：NSFC-广东联合基金重点支持项目，流感病毒抗原特异性TCR组库数据库的建立及应用。项目编码: U1801285。项目预算：245万元。2019/01/01-2022/12/31
3. 国家科技部，国家重点研发计划“主动健康与老龄化科技应对”重点专项，“中国老年人群衰弱的诊断标准及综合干预研究”专项，课题“基于新方法新技术的老年衰弱早期预测和诊断研究”总负责人，华南区召集人。项目编码：2018YFC2002003。项目预算：488万。2019/01/01-2023/12/31
4. 广州市科技计划项目：单细胞水平TCR组学高通量测序技术的建立与应用。项目编码：201904010111，项目预算：20万元。2019/04/01-2022/03/31
5. 国家自然科学基金委：应急项目，单细胞转录组学和TCR组学分析老年人巨细胞病毒和流感病毒抗原特异性CD8 T细胞免疫应答的差异研究。项目编码：31741037，项目预算：15万元。2018/01/01-2018/12/31
6. 广东省建设高水平大学人才引进项目：T淋巴细胞TCR组库的鉴定及功能研究。项目预算：100万元。2018/01/01-2023/12/31
1.Luo OJ, Lei W, Zhu G, Ren Z, Xu Y, Xiao C, Zhang H, Cai J, Luo Z, Gao L, Su J, Tang L, Guo W, Su H, Zhang Z-J, Fang EF, Ruan Y, Leng SX, Ju Z, Lou H, Gao J, Peng N, Chen J, Bao Z, Liu F, Chen G. Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty. Nature Aging 2022, 2(4): 348-364.
2.Ye J, Lei W, Xiao C, Su X, Gao J, Li X, Li W, Wang P, Jiang Z, Chen G. Production and purification of infectious diseases-associated tetramer for staining of CD8(+) T cells from PBMCs. STAR Protoc 2022, 3(1): 101206.
3.Xiao C, Mao L, Wang Z, Gao L, Zhu G, Su J, Chen X, Yuan J, Hu Y, Yin Z, Xie J, Ji W, Niu H, Gao F, Luo OJ, Xiao L, Wang P, Chen G. SARS-CoV-2 variant B.1.1.7 caused HLA-A2(+) CD8(+) T cell epitope mutations for impaired cellular immune response. iScience 2022, 25(3): 103934.
4.Song K, Zeng X, Xie X, Zhu R, Liang J, Chen G, Huang L. Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance. Stroke Vasc Neurol 2022.
5.Jia H, Liu C, Li D, Huang Q, Liu D, Zhang Y, Ye C, Zhou D, Wang Y, Tan Y, Li K, Lin F, Zhang H, Lin J, Xu Y, Liu J, Zeng Q, Hong J, Chen G, Zhang H, Zheng L, Deng X, Ke C, Gao Y, Fan J, Di B, Liang H. Metabolomic analyses reveal new stage-specific features of COVID-19. Eur Respir J 2022, 59(2).
6.Xu C, Wu J, Wu Y, Ren Z, Yao Y, Chen G, Fang EF, Noh JH, Liu YU, Wei L, Chen X, Sima J. TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG. Theranostics 2021, 11(19): 9452-9469.
7.Xiao C, Qiu C, Deng J, Ye J, Gao L, Su J, Luo OJ, Wang P, Chen G. Optimization of antigen-specific CD8(+) T cell activation conditions for infectious diseases including COVID-19. STAR Protoc 2021, 2(3): 100789.
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9.Ma Y, Guo R, Sun Y, Li X, He L, Li Z, Silverman GJ, Chen G, Gao F, Yuan J, Wei Q, Li M, Lu L, Niu H. Lupus gut microbiota transplants cause autoimmunity and inflammation. Clin Immunol 2021, 233: 108892.
10.Lu K, Lai KP, Stoeger T, Ji S, Lin Z, Lin X, Chan TF, Fang JK, Lo M, Gao L, Qiu C, Chen S, Chen G, Li L, Wang L. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology. J Hazard Mater 2021, 416: 126069.
11.Li X, Li H, Cai D, Li P, Jin J, Jiang X, Li Z, Tian L, Chen G, Sun J, Bai W. Chronic oral exposure to cadmium causes liver inflammation by NLRP3 inflammasome activation in pubertal mice. Food Chem Toxicol 2021, 148: 111944.
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13.Yan Y, Wang G, Huang J, Zhang Y, Cheng X, Chuai M, Brand-Saberi B, Chen G, Jiang X, Yang X. Zinc oxide nanoparticles exposure-induced oxidative stress restricts cranial neural crest development during chicken embryogenesis. Ecotoxicol Environ Saf 2020, 194: 110415.
14.Fang EF, Xie C, Schenkel JA, Wu C, Long Q, Cui H, Aman Y, Frank J, Liao J, Zou H, Wang NY, Wu J, Liu X, Li T, Fang Y, Niu Z, Yang G, Hong J, Wang Q, Chen G, Li J, Chen HZ, Kang L, Su H, Gilmour BC, Zhu X, Jiang H, He N, Tao J, Leng SX, Tong T, Woo J. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Res Rev 2020, 64: 101174.
15.Zhang Z, Sun M, Deng J, Yu J, Yang X, Zhao W, Chen G, Wang P. Zika Virus Induced More Severe Inflammatory Response Than Dengue Virus in Chicken Embryonic Livers. Front Microbiol 2019, 10: 1127.
16.Chen G, Yung R. Meta-inflammaging at the crossroad of geroscience. Aging Med (Milton) 2019, 2(3): 157-161.
17.Chen G, Subedi K, Chakraborty S, Sharov A, Lu J, Kim J, Mi X, Wersto R, Sung MH, Weng NP. Ezh2 Regulates Activation-Induced CD8(+) T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression. Front Immunol 2018, 9: 549.
18.Chen G, Bodogai M, Tamehiro N, Shen C, Dou J. Cancer Immunotherapy: Theory and Application. J Immunol Res 2018, 2018: 7502161.
19.Yang X, Chen G, Weng NP, Mariuzza RA. Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope. J Biol Chem 2017, 292(45): 18618-18627.
20.Chen G, Yang X, Ko A, Sun X, Gao M, Zhang Y, Shi A, Mariuzza RA, Weng NP. Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8(+) TCR Repertoires to Immunodominant Viral Antigens. Cell Rep 2017, 19(3): 569-583.
21.Li HM, Hiroi T, Zhang Y, Shi A, Chen G, De S, Metter EJ, Wood WH, 3rd, Sharov A, Milner JD, Becker KG, Zhan M, Weng NP. TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition. J Leukoc Biol 2016, 99(3): 505-513.
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23.Slota C, Shi A, Chen G, Bevans M, Weng NP. Norepinephrine preferentially modulates memory CD8 T cell function inducing inflammatory cytokine production and reducing proliferation in response to activation. Brain Behav Immun 2015, 46: 168-179.
24.Najarro K, Nguyen H, Chen G, Xu M, Alcorta S, Yao X, Zukley L, Metter EJ, Truong T, Lin Y, Li H, Oelke M, Xu X, Ling SM, Longo DL, Schneck J, Leng S, Ferrucci L, Weng NP. Telomere Length as an Indicator of the Robustness of B- and T-Cell Response to Influenza in Older Adults. J Infect Dis 2015, 212(8): 1261-1269.
25.Li HM, Hiroi T, Zhang Y, Shi A, Chen G, De S, Metter EJ, Wood WH, 3rd, Sharov A, Milner JD, Becker KG, Zhan M, Weng NP. TCRbeta repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition. J Leukoc Biol 2015.
26.Chen G, Shannon M. Transcription factors and th17 cell development in experimental autoimmune encephalomyelitis. Crit Rev Immunol 2013, 33(2): 165-182.
27.Chen G, Lustig A, Weng NP. T cell aging: a review of the transcriptional changes determined from genome-wide analysis. Front Immunol 2013, 4: 121.
28.Li Y, Chen G, Ma L, Ohms SJ, Sun C, Shannon MF, Fan JY. Plasticity of DNA methylation in mouse T cell activation and differentiation. BMC Mol Biol 2012, 13: 16.
29.Chen G, Weng NP. Analyzing the phenotypic and functional complexity of lymphocytes using CyTOF (cytometry by time-of-flight). Cell Mol Immunol 2012, 9(4): 322-323.
30.Chen G, Hardy K, Pagler E, Ma L, Lee S, Gerondakis S, Daley S, Shannon MF. The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J Immunol 2011, 187(9): 4483-4491.
31.Chen G, Hardy K, Bunting K, Daley S, Ma L, Shannon MF. Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel. J Immunol 2010, 185(4): 2350-2359.
32.Tang W, Chen G, Gu Q, Pan J, Wu W. Expression, purification and identification of recombinant mouse interleukin 21 protein in E. coli. Cell Mol Immunol 2006, 3(4): 311-315.
33.Dou J, Hong X, Zhao F, Wang J, Chen J, Chen G. Investigation of GM-CSF immune accessory effects in tumor-bearing mice by direct gene immunization. Immunol Invest 2006, 35(2): 227-237.
34.Chen GB, Meng JH. Identification of 5' capped structure and 3' terminal sequence of hepatitis E virus isolated from Morocco. World J Gastroenterol 2004, 10(14): 2045-2049.
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