Publication
2020-2022
1.Luo OJ, Lei W, Zhu G, Ren Z, Xu Y, Xiao C, Zhang H, Cai J, Luo Z, Gao L, Su J, Tang L, Guo W, Su H, Zhang Z-J, Fang EF, Ruan Y, Leng SX, Ju Z, Lou H, Gao J, Peng N, Chen J, Bao Z, Liu F, Chen G. Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty. Nature Aging 2022, 2(4): 348-364.
2.Ye J, Lei W, Xiao C, Su X, Gao J, Li X, Li W, Wang P, Jiang Z, Chen G. Production and purification of infectious diseases-associated tetramer for staining of CD8(+) T cells from PBMCs. STAR Protoc 2022, 3(1): 101206.
3.Xiao C, Mao L, Wang Z, Gao L, Zhu G, Su J, Chen X, Yuan J, Hu Y, Yin Z, Xie J, Ji W, Niu H, Gao F, Luo OJ, Xiao L, Wang P, Chen G. SARS-CoV-2 variant B.1.1.7 caused HLA-A2(+) CD8(+) T cell epitope mutations for impaired cellular immune response. iScience 2022, 25(3): 103934.
4.Song K, Zeng X, Xie X, Zhu R, Liang J, Chen G, Huang L. Dl-3-n-butylphthalide attenuates brain injury caused by cortical infarction accompanied by cranial venous drainage disturbance. Stroke Vasc Neurol 2022.
5.Jia H, Liu C, Li D, Huang Q, Liu D, Zhang Y, Ye C, Zhou D, Wang Y, Tan Y, Li K, Lin F, Zhang H, Lin J, Xu Y, Liu J, Zeng Q, Hong J, Chen G, Zhang H, Zheng L, Deng X, Ke C, Gao Y, Fan J, Di B, Liang H. Metabolomic analyses reveal new stage-specific features of COVID-19. Eur Respir J 2022, 59(2).
6.Xu C, Wu J, Wu Y, Ren Z, Yao Y, Chen G, Fang EF, Noh JH, Liu YU, Wei L, Chen X, Sima J. TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG. Theranostics 2021, 11(19): 9452-9469.
7.Xiao C, Qiu C, Deng J, Ye J, Gao L, Su J, Luo OJ, Wang P, Chen G. Optimization of antigen-specific CD8(+) T cell activation conditions for infectious diseases including COVID-19. STAR Protoc 2021, 2(3): 100789.
8.Qiu C, Xiao C, Wang Z, Zhu G, Mao L, Chen X, Gao L, Deng J, Su J, Su H, Fang EF, Zhang ZJ, Zhang J, Xie C, Yuan J, Luo OJ, Huang LA, Wang P, Chen G. CD8(+) T-Cell Epitope Variations Suggest a Potential Antigen HLA-A2 Binding Deficiency for Spike Protein of SARS-CoV-2. Front Immunol 2021, 12: 764949.
9.Ma Y, Guo R, Sun Y, Li X, He L, Li Z, Silverman GJ, Chen G, Gao F, Yuan J, Wei Q, Li M, Lu L, Niu H. Lupus gut microbiota transplants cause autoimmunity and inflammation. Clin Immunol 2021, 233: 108892.
10.Lu K, Lai KP, Stoeger T, Ji S, Lin Z, Lin X, Chan TF, Fang JK, Lo M, Gao L, Qiu C, Chen S, Chen G, Li L, Wang L. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology. J Hazard Mater 2021, 416: 126069.
11.Li X, Li H, Cai D, Li P, Jin J, Jiang X, Li Z, Tian L, Chen G, Sun J, Bai W. Chronic oral exposure to cadmium causes liver inflammation by NLRP3 inflammasome activation in pubertal mice. Food Chem Toxicol 2021, 148: 111944.
12.Deng J, Pan J, Qiu M, Mao L, Wang Z, Zhu G, Gao L, Su J, Hu Y, Luo OJ, Chen G, Wang P. Identification of HLA-A2 restricted CD8(+) T cell epitopes in SARS-CoV-2 structural proteins. J Leukoc Biol 2021, 110(6): 1171-1180.
13.Yan Y, Wang G, Huang J, Zhang Y, Cheng X, Chuai M, Brand-Saberi B, Chen G, Jiang X, Yang X. Zinc oxide nanoparticles exposure-induced oxidative stress restricts cranial neural crest development during chicken embryogenesis. Ecotoxicol Environ Saf 2020, 194: 110415.
14.Fang EF, Xie C, Schenkel JA, Wu C, Long Q, Cui H, Aman Y, Frank J, Liao J, Zou H, Wang NY, Wu J, Liu X, Li T, Fang Y, Niu Z, Yang G, Hong J, Wang Q, Chen G, Li J, Chen HZ, Kang L, Su H, Gilmour BC, Zhu X, Jiang H, He N, Tao J, Leng SX, Tong T, Woo J. A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks. Ageing Res Rev 2020, 64: 101174.
2004-2020
15.Zhang Z, Sun M, Deng J, Yu J, Yang X, Zhao W, Chen G, Wang P. Zika Virus Induced More Severe Inflammatory Response Than Dengue Virus in Chicken Embryonic Livers. Front Microbiol 2019, 10: 1127.
16.Chen G, Yung R. Meta-inflammaging at the crossroad of geroscience. Aging Med (Milton) 2019, 2(3): 157-161.
17.Chen G, Subedi K, Chakraborty S, Sharov A, Lu J, Kim J, Mi X, Wersto R, Sung MH, Weng NP. Ezh2 Regulates Activation-Induced CD8(+) T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression. Front Immunol 2018, 9: 549.
18.Chen G, Bodogai M, Tamehiro N, Shen C, Dou J. Cancer Immunotherapy: Theory and Application. J Immunol Res 2018, 2018: 7502161.
19.Yang X, Chen G, Weng NP, Mariuzza RA. Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope. J Biol Chem 2017, 292(45): 18618-18627.
20.Chen G, Yang X, Ko A, Sun X, Gao M, Zhang Y, Shi A, Mariuzza RA, Weng NP. Sequence and Structural Analyses Reveal Distinct and Highly Diverse Human CD8(+) TCR Repertoires to Immunodominant Viral Antigens. Cell Rep 2017, 19(3): 569-583.
21.Li HM, Hiroi T, Zhang Y, Shi A, Chen G, De S, Metter EJ, Wood WH, 3rd, Sharov A, Milner JD, Becker KG, Zhan M, Weng NP. TCRβ repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition. J Leukoc Biol 2016, 99(3): 505-513.
22.Yang X, Gao M, Chen G, Pierce BG, Lu J, Weng NP, Mariuzza RA. Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope. J Biol Chem 2015, 290(48): 29106-29119.
23.Slota C, Shi A, Chen G, Bevans M, Weng NP. Norepinephrine preferentially modulates memory CD8 T cell function inducing inflammatory cytokine production and reducing proliferation in response to activation. Brain Behav Immun 2015, 46: 168-179.
24.Najarro K, Nguyen H, Chen G, Xu M, Alcorta S, Yao X, Zukley L, Metter EJ, Truong T, Lin Y, Li H, Oelke M, Xu X, Ling SM, Longo DL, Schneck J, Leng S, Ferrucci L, Weng NP. Telomere Length as an Indicator of the Robustness of B- and T-Cell Response to Influenza in Older Adults. J Infect Dis 2015, 212(8): 1261-1269.
25.Li HM, Hiroi T, Zhang Y, Shi A, Chen G, De S, Metter EJ, Wood WH, 3rd, Sharov A, Milner JD, Becker KG, Zhan M, Weng NP. TCRbeta repertoire of CD4+ and CD8+ T cells is distinct in richness, distribution, and CDR3 amino acid composition. J Leukoc Biol 2015.
26.Chen G, Shannon M. Transcription factors and th17 cell development in experimental autoimmune encephalomyelitis. Crit Rev Immunol 2013, 33(2): 165-182.
27.Chen G, Lustig A, Weng NP. T cell aging: a review of the transcriptional changes determined from genome-wide analysis. Front Immunol 2013, 4: 121.
28.Li Y, Chen G, Ma L, Ohms SJ, Sun C, Shannon MF, Fan JY. Plasticity of DNA methylation in mouse T cell activation and differentiation. BMC Mol Biol 2012, 13: 16.
29.Chen G, Weng NP. Analyzing the phenotypic and functional complexity of lymphocytes using CyTOF (cytometry by time-of-flight). Cell Mol Immunol 2012, 9(4): 322-323.
30.Chen G, Hardy K, Pagler E, Ma L, Lee S, Gerondakis S, Daley S, Shannon MF. The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis. J Immunol 2011, 187(9): 4483-4491.
31.Chen G, Hardy K, Bunting K, Daley S, Ma L, Shannon MF. Regulation of the IL-21 gene by the NF-κB transcription factor c-Rel. J Immunol 2010, 185(4): 2350-2359.
32.Tang W, Chen G, Gu Q, Pan J, Wu W. Expression, purification and identification of recombinant mouse interleukin 21 protein in E. coli. Cell Mol Immunol 2006, 3(4): 311-315.
33.Dou J, Hong X, Zhao F, Wang J, Chen J, Chen G. Investigation of GM-CSF immune accessory effects in tumor-bearing mice by direct gene immunization. Immunol Invest 2006, 35(2): 227-237.
34.Chen GB, Meng JH. Identification of 5' capped structure and 3' terminal sequence of hepatitis E virus isolated from Morocco. World J Gastroenterol 2004, 10(14): 2045-2049.
35.Chen GB, Dou J, Chen JS, Hong XW. [Cloning and eukaryotic expression of mouse interleukin 21]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2004, 20(1): 49-52.